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Academic Report: Chemical Synthesis: Enabling Technology and Enigmatic Challenge



TopicChemical Synthesis: Enabling Technology and Enigmatic Challenge

TimeAt 15:00, July 6 (Friday), 2018

Venue: Auditorium, 18th Floor, Century Building, East Campus

Lecturer: Gregory B. Dudley

Lecturer Profile

Gregory B. Dudley is the Eberly Family Distinguished Professor of Chemistry and Department Chair of the C. Eugene Bennett Department of Chemistry at West Virginia University in Morgantown, WV. Prof Dudley received a B.A. from FSU in1995 and a Ph.D. from MIT in 2000 under the direction of Prof. Rick Danheiser. After receiving an NIH Postdoctoral Fellowship to work with Prof. Samuel Danishefsky at the Sloan–Kettering Institute for Cancer Research, he returned to FSU as an Assistant Professor in 2002. He was promoted to the rank of Associate Professor with tenure in 2008 and to Full Professor in 2015 before moving to WVU in July 2016. Professor Dudley has been recognized with awards for innovation, scholarship, and classroom teaching. Research efforts in his independent career have resulted in over 70 publications, 160 presentations, and multiple patents related to two commercial products. The current mission of his research program is to impact the drug discovery and development processes by contributing fundamental knowledge in organic chemistry, including new strategies, tactics, and research tools for best practices in organic synthesis.

Lecture content:

Research in the Dudley Lab is designed to further the science and practice of organic chemistry. This seminar will cover two disparate topics linked by a focus on expanding the power of chemical synthesis, an enabling technology for all of the molecular sciences. The first part features “alkynogenic fragmentation” methodology: C–C bond-cleaving anionic fragmentation reactions that generate alkynes. It focuses on alkyne chemistry in the context of important problems in the chemical synthesis of bioactive natural products. The second part of the seminar addresses enigmas surrounding the use of microwave electromagnetic radiation to promote thermal chemical reactions. Organic reaction mixtures are typically heated convectively, and the physics of convective heat transfer underlies all of physical organic theory. Microwave energy, in contrast, produces heat by fundamentally different mechanisms, which need to be understood in order for us to gain maximum benefit from this new technology. Examples and a physical model for selective heating in solution will be presented and discussed.

All are welcome.

School of Environmental and Chemical Engineering

July 3, 2018

[Translated by Liu Ruo]

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